GNAcode, Denmark

GNAcode, Denmark

Featured Date: 16th December 2015

Website:  www.gnacode.com

GNAcode ApS (GNAcode) was formed as a collaboration between TMB Labs and Xtel ApS in 2015. The company aspires to combine the expertise of life sciences researchers and information technology professionals to create highly sensitive, precise and innovative life science instruments. The company aims to develop a series of products which are accessible by a single interface. The interface is iOS, which enables control of devices through an iPad.

One of the proprietary products of the company is Minicube PCR. This is a 16-well thermo-cycler capable of running 16 different PCR protocols at the same time. The device allows for individual temperature control in each well by the use of high-quality platinum sensors. This results in minimized well-to-well variations, which is the main artifact in many PCR experiments. The uniqueness of the product is, it combines current trends such as miniaturization, precision, speed in its design.

The product offers operational advantages such as execution of parallel as well as timed PCR experiments and multiple incubations. In addition, it offers the benefit of experiment optimization and rapid development of test protocols. The device can also ameliorate the effects caused due to ‘PCR bias’ amplification arising from PCR experiments.

The company’s technology originated in 2002 when a fully automated PCB (printed circuit board)-based PCR chip was developed for biothreat detection. The company later developed this prototype as Minicube PCR. According to GNAcode, the product can complete 35 cycles per PCR reaction in about 15 minutes in standard mode.

The product could find applications in several areas ranging from improved library generation for NGS, phylogenetic studies, and diagnostics assay design. In addition, it may also prove useful in low-input experiments such as ctDNA (circulating tumor DNA), and for low-quality samples such as FFPE (Formalin-Fixed Paraffin-Embedded) specimens.

The company is in the process of developing a mobile application to enable monitoring of Minicube PCR via wireless networks. This allows for real-time control and sharing of experiment status among multiple users. Open-source software is also offered by the company to add other functionalities.

The company has recently launched the demo versions of the product in USA and UK.