The Next Generation Sequencing (NGS) Markets in Japan

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Japan’s NGS Market and COVID-19 Impact Analysis: By application, method, product types, and Companies

An in-depth look at the NGS market growth trends in the clinical as well as non-clinical segments in Japan (2019-2024 period), along with the impact of COVID-19 in 2020 and its impact on the demand forecast.

This report analyses the market trends influencing various NGS market segments in Japan. This is an updated version of the study conducted in 2019. It also analyses the global market trends, which have a significant impact on Japan’s NGS market.

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Description

  • Japan’s NGS Market and COVID-19 Impact Analysis: By application, method, product types, and Companies

    An in-depth look at the NGS market growth trends in the clinical as well as non-clinical segments in Japan (2019-2024 period), along with the impact of COVID-19 in 2020 and its impact on the demand forecast.

    This report analyses the market trends influencing various NGS market segments in Japan. This is an updated version of the study conducted in 2019. It also analyses the global market trends, which have a significant impact on Japan’s NGS market.

    The estimations and forecasts in the original version have been revisited for accommodating the impact of COVID-19, which has affected all the sub-segments across the NGS markets in Japan. The base year of the study is maintained as 2019 since the pandemic situation is still evolving and the impact is uncertain to a large extent. The original estimates for each market segment have been revised for 2020 and beyond in this updated version. Response to COVID-19 by each leading market player in Japan has also been evaluated in detail.

    This report segments Japan’s NGS market with respect to methods, applications, and product as well as service types. The drivers and restraints of segments are evaluated for estimating market size, forecast, and COVID-19 impact. The profiles of leading players in the global, as well as Japanese markets, are studied in detail along with their response to the pandemic and impact on their NGS revenues in 2020. The report also includes a detailed analysis of the regulatory as well as the reimbursement landscapes in Japan that play a major role in shaping the NGS market, particularly related to the clinical diagnostics end-use segments. The report has a total of 310 pages, which includes more than 50 tables.

    This report derives competitive intelligence on the business strategies of the end-users as well as key market players. It also offers an overview of the opportunities and challenges in the market, along with the emerging unmet needs that the key NGS market players can target. Custom research to derive additional insights on the existing opportunities is possible for buyers of the report at a small additional fee based on the scope required.

  • Executive Summary 

    Summary Table: The NGS Market Size and Forecast in Japan (USD, Million)

    Impact of COVID-19 Pandemic

    Market Overview 

    NGS Workflow 

    Library Preparation and Amplification

    Sequencing

    Data Analysis

    NGS Market Trends

    Market Drivers

    Technological Advancements

    Declining Costs

    Precision Medicine Initiatives

    Health Insurance Coverage

    Increasing Demand from Clinical Applications Segments

    Growing Investments in Companion Diagnostics (CDx) Development

    Market Restraints

    Impact of COVID-19

    High Costs Compared to Alternative Genomic Platforms

    Lack of Effective Software Solutions for Data Management and Downstream Analysis

    NSG Data Management, Interpretation and Sharing: Ethical and Legal Issues

    Lack of Geneticists

    Lack of Awareness

    Market Entry Barriers for New Comers

    Health Insurance Landscape in Japan

    Table 1: Government Agencies Responsible for Health Policy in Japan

    Public Health Insurance in Japan

    Residence-based National Health Insurance (NHI)

    Employer-based Health Insurance

    Health Insurance for the Elderly

    Private Health Insurance in Japan

    Reimbursement Fee Decision Process in Japan

    Health Insurance Coverage for Sequencing Tests

    Table 2: NGS-based Clinical Diagnostics Tests with Insurance Coverage in Japan

    Regulatory Landscape Promoting NGS in Japan

    Regulatory Options for NGS-based Tests

    Genomic Data Sharing Policies

    Regulatory Process for Companion Diagnostics

    Table 3: Regulatory Process for Companion Diagnostics Approval in Japan

    The NGS Market Landscape in Japan

    Industry Consolidation Trends

    Setbacks to Industry Consolidation

    Partnerships Focusing on NGS Services and Other Segments

    NGS Market in Japan and Impact of COVID-19 Pandemic

    Table 4: The NGS Market Size and Forecast in Japan (2019-2024; USD, Million)

    NGS Markets in Japan by Methods

    Targeted Genome Sequencing and Resequencing

    Table 5: NGS Panels Approved for Clinical Diagnostics Applications in Japan

    Whole Genome Sequencing (WGS)

    Large-Scale WGS Studies on Japanese Population

    Table 6: Selected List of Large-Scale WGS Projects in Japan

    Table 7: Selected List of Organisations Conducting Large-Scale WGS Projects in Japan

    Whole Exome Sequencing (WES)

    Table 8: Selected List of Large Scale WES Projects in Japan

    RNA-Seq

    Commercial Platforms, Kits and Data Analysis Products for RNA-seq

    Table 9: Selected list of Companies Offering RNA-Seq Library Preparation Kits

    mRNA-Seq

    Non-Coding RNA-seq

    Single-cell RNA-seq (scRNA-seq)

    Table 10: Selected Cell Isolation and Library Preparation Platforms in the Market for scRNA-Seq. 70

    Table 11: Selected List of scRNA-Seq Data Analysis Products

    Transcriptomics Moving from Microarrays to RNA-seq

    Other NGS Methods

    The Market Size and Growth Trends of the Leading NGS Methods

    Table 12: The NGS Market Size and Forecast in Japan by Method (2019-2024; USD, Million)

    NGS Markets in Japan by Products and Services

    Instruments

    Single Cell Sequencing

    Table 13: Popular NGS Platforms in the Japanese Market

    NGS Workflow Automation

    Table 14: Selected List of Products Facilitating Automation of NGS and their Suppliers

    Consumables and Accessories

    Table 15: Selected List of NGS Library Preparation Products in Japan for Research Use

    Bioinformatics Tools for NGS

    Primary Data Analysis

    Secondary Data Analysis

    Tertiary Data Analysis

    Table 16: Commonly Used Bioinformatics Tools for NGS: For Primary, Secondary, and Tertiary Data Analysis

    Rising Influence of Cloud Computing

    Key Challenges of NGS Data Analysis Players

    Role of Reference Laboratories as NGS Moves to Clinical Diagnostics in Japan

    NGS Data Analysis in Japan: Key Players and Capabilities

    NGS Service Providers in Japan

    Table 17: Selected List of Leading NGS service Providers in Japan

    NGS Market Size and Growth Trends in Japan by Products and Services

    Table 18: The NGS Market Size and Forecasts in Japan by Products and Services (2019-2024; USD, Million)

    NGS Markets in Japan by Application Segments

    Clinical Diagnostics

    The Clinical Genetics Medical Care System in Japan

    Table 19: Selected List of Associations influencing Clinical Genetics in Japan

    Genetic Counsellor Certification System in Japan

    Concerns Regarding Genetic Information Abuse Potentials

    NGS-based Cancer Diagnostics in Japan

    Regulations Influencing NGS-based Cancer Diagnosis in Japan

    Table 20: The Basic Plan to Promote Cancer Control Programs in Japan

    Guidelines for NGS-based Gene Panel Tests for Cancer in Japan

    Table 21: Evidence Levels as per the Guidance for Gene Panel Testing of Solid Cancers in Japan

    NGS-based CDx Tests for Cancer in Japan: Regulations and Reimbursement Status

    Concerns about Accuracy of NGS-based Cancer Diagnostics for Japanese Population

    Gene Panel Tests Dominate NGS-based Cancer Diagnostics Segment

    Approved NGS-based Gene Panel Tests for Cancer in Japan

    Table 22: NGS-based Gene Panel Tests for Cancer Diagnostics in Japan

    Reimbursement for Gene Panel Tests for Cancer in Japan

    NGS-based Cancer Diagnostics: Infrastructure and Other Challenges in Japan

    NGS-based Precision Oncology Initiatives and their Influence in Clinical Diagnostics in Japan

    Influence of Academia in Driving Gene Panel Tests Demand

    The Future of NGS-based Cancer Diagnostics in Japan

    Table 23: Core Hospitals Designated for Cancer Genomic Medicine across Japan

    NGS-based Reproductive Health Diagnostics in Japan

    The Rising Global Demand for NIPT

    Table 24: Diseases and Aneuploidies Commonly Tested by NIPT Assays

    Table 25: Selected List of NGS-based NIPT Tests in the Global Market

    NIPT Market – An Assessment of the IP Landscape of NGS Platforms

    Rising Investments in the New-born and Prenatal Testing Markets

    Prenatal Testing Insurance Coverage Status: Japan Vs Other Regulated Markets

    Reproductive Health Focus of the Japanese Society and Bioethics Concerns

    Regulatory Status of Preimplantation Genetic Testing (PGT) in Japan

    Availability of NGS-based New-born and Prenatal Tests in Japan

    Table 26: New-born Screening Program in Japan: Incidences of Diseases Targeted

    The Issue of Unauthorised NIPT Service Providers in Japan

    NGS Demand in Other Clinical Diagnostics Segments

    Infectious Diseases

    Tuberculosis

    SARS-CoV-2 Testing

    HLA Typing

    Direct-to-Consumer (DTC) Genetic Testing

    The Evolving Regulatory Landscape of DTC Genetic Testing

    Regulatory Scrutiny Triggering Novel Consumer Genomics Business Models

    Legal Framework for DTC Genetic Testing in Japan

    Genomic Software Firms Filling the Gap of Genetic Counsellors

    Online Availability of DTC Genetic Tests

    Acceptance of DTC Genetic Tests in Medical Fields

    Status of DTC Genetic Testing in Japan

    Emerging Consumer Genomics Applications Attracting New Investments in Japan

    Research Applications

    Academic Research

    Table 27: Selected Institutions in Japan Active in NGS Research/ Research Services

    Large-Scale Genome-wide Sequencing Projects in Japan

    Table 28: Selected List of Large Scale Genome-wide Sequencing (GWS) Projects in Japan

    Influence of Public-Private Partnership

    Industry R&D

    Other Emerging NGS Application Segments

    Table 29: The NGS Market Size and Forecasts in Japan by Application Segments (2019-2024; USD, Million)

    Company Profiles

    10x Genomics, Inc

    10x Genomics Products and Response to COVID-19

    Table 30: Selected List of NGS Products Offered by 10x Genomics

    Impact of COVID-19 Pandemic

    Acquisitions and Partnerships

    Table 31: Selected List of Partnerships and Acquisitions of 10x Genomics

    Activities in the Japanese Market

    Agilent Technologies

    NGS Products Offered by Agilent

    Impact of COVID-19 in Agilent’s NGS Business

    BGI Group

    BGI Genomics Co Ltd and MGI Tech

    Table 32: Sequencers Produced and Marketed by the BGI Group

    Table 33: NGS-based Assays and Services Provided by BGI Group

    Partnerships and Collaborations

    Table 34: Selected List of Recent Partnerships of BGI Group*

    Response to COVID-19

    BGI in Japan’s NGS Market

    Eurofins Scientific S.E.

    Global Expansion through Innovation and Acquisitions

    Role in the NGS Market

    Response to COVID-19

    Presence in Japan’s NGS Market

    F. Hoffmann-La Roche Ltd

    Response to COVID-19

    NGS Products and Services

    Table 35: Acquisitions and Partnerships Related to Roche’s NGS Business

    Japan Updates

    Foundation Medicine, Inc

    Products and Services

    Impact of COVID-19 Pandemic

    Partnerships

    Table 36: Selected List of Partnerships and Collaborations of Foundation Medicine

    Foundation Medicine in Japan

    Genesis Healthcare Co., Japan

    Products and Services

    Table 37: Genetic Testing offered under GeneLife Brand by Genesis Healthcare

    GeneQuest Co. Ltd

    Genewiz (Japan Genewith Co,, Ltd)

    Role in the NGS Market

    Activities in Japan

    Illumina

    Expanding Consumer Segments

    NGS Business – Strategies, Products, and Services

    Table 38: Selected List of Sequencing Systems offered by Illumina

    Table 39: Selected List of Assays Offered by Illumina

    Response to COVID-19 Pandemic

    Focus on Innovation and Related Investments

    Clinical Diagnostics Strategies

    Table 40: Selected List of Partnerships Targeting Diagnostics Applications

    Illumina in Japan’s NGS Market

    Macrogen Inc

    NGS Services Offered by Macrogen

    Table 41: Gene Panel Tests Offered by Macrogen

    Collaborations and Partnerships

    Table 42: Selected List of Partnerships and Collaborations of Macrogen*

    Response to COVID-19

    Activities in the Japanese Market

    Oxford Nanopore Technologies

    Table 43: Sequencers produced by Oxford Nanopore Technologies

    Response to COVID-19 Pandemic

    Partnerships and Collaborations

    Table 44: Selected List of Recent Partnerships of Oxford Nanopore Technologies

    Activities in the Japanese Market

    Pacific Biosciences of California, Inc

    Table 45: Selected List of the Products Offered by PacBio

    Partnerships and Collaborations

    Table 46: Selected List of Partnerships of PacBio in the last 5 years

    Impact of COVID-19 Pandemic

    Activities in Japan’s NGS Market

    Perkin Elmer Inc

    Response to COVID-19

    NGS Products and Services

    Table 47: Selected NGS Products of Perkin Elmer

    Perkin Elmer in Japan

    Qiagen N. V

    COVID-19 Pandemic Effect on NGS Business

    NGS business of Qiagen

    Qiagen in Japan’s NGS Market

    RIKEN Genesis Co. Ltd

    Partnerships

    Table 48: Selected List of Partnerships of RIKEN Genesis

    Sysmex Corporation

    Response to COVID-19

    Role in Japan’s NGS Market

    Takara Bio Inc

    NGS Products and Services

    Impact of the COVID-19 pandemic

    Partnerships and Agreements

    Table 49: Partnerships and Collaborations of Takara Bio in the past 5 years

    Thermo Fisher Scientific Inc

    Response to COVID-19 pandemic

    Partnerships and Acquisitions

    Table 50: Selected Partnerships and Acquisitions of Thermo Fisher (2017-2020)

    NGS Products and Services

    Table 51: NGS Instruments Offered by Thermo Fisher Scientific

    Table 52: Selected List of NGS-based Assays and Services of Thermo Fisher Scientific

    Thermo Fisher Scientific in Japan’s NGS Market

    Glossary

    LIST OF TABLES

    SUMMARY TABLE: THE NGS MARKET SIZE AND FORECAST IN JAPAN (USD, MILLION)

    TABLE 1: GOVERNMENT AGENCIES RESPONSIBLE FOR HEALTH POLICY IN JAPAN

    TABLE 2: NGS-BASED CLINICAL DIAGNOSTICS TESTS WITH INSURANCE COVERAGE IN JAPAN

    TABLE 3: REGULATORY PROCESS FOR COMPANION DIAGNOSTICS APPROVAL IN JAPAN

    TABLE 4: THE NGS MARKET SIZE AND FORECAST IN JAPAN (2019-2024; USD, MILLION

    TABLE 5: NGS PANELS APPROVED FOR CLINICAL DIAGNOSTICS APPLICATIONS IN JAPAN

    TABLE 6: SELECTED LIST OF LARGE-SCALE WGS PROJECTS IN JAPAN

    TABLE 7: SELECTED LIST OF ORGANISATIONS CONDUCTING LARGE-SCALE WGS PROJECTS IN JAPAN

    TABLE 8: SELECTED LIST OF LARGE SCALE WES PROJECTS IN JAPAN

    TABLE 9: SELECTED LIST OF COMPANIES OFFERING RNA-SEQ LIBRARY PREPARATION KITS

    TABLE 10: SELECTED CELL ISOLATION AND LIBRARY PREPARATION PLATFORMS IN THE MARKET FOR SCRNASEQ

    TABLE 11: SELECTED LIST OF SCRNA-SEQ DATA ANALYSIS PRODUCTS

    TABLE 12: THE NGS MARKET SIZE AND FORECAST IN JAPAN BY METHOD (2019-2024; USD, MILLION)

    TABLE 13: POPULAR NGS PLATFORMS IN THE JAPANESE MARKET

    TABLE 14: SELECTED LIST OF PRODUCTS FACILITATING AUTOMATION OF NGS AND THEIR SUPPLIERS

    TABLE 15: SELECTED LIST OF NGS LIBRARY PREPARATION PRODUCTS IN JAPAN FOR RESEARCH USE

    TABLE 16: COMMONLY USED BIOINFORMATIC TOOLS FOR NGS: FOR PRIMARY, SECONDARY, AND TERTIARY

    DATA ANALYSIS

    TABLE 17: SELECTED LIST OF LEADING NGS SERVICE PROVIDERS IN JAPAN

    TABLE 18: THE NGS MARKET SIZE AND FORECASTS IN JAPAN BY PRODUCTS AND SERVICES (2019-2024; USD,Million)

    TABLE 19: SELECTED LIST OF ASSOCIATIONS INFLUENCING CLINICAL GENETICS IN JAPAN

    TABLE 20: THE BASIC PLAN TO PROMOTE CANCER CONTROL PROGRAMS IN JAPAN

    TABLE 21: EVIDENCE LEVELS AS PER THE GUIDANCE FOR GENE PANEL TESTING OF SOLID CANCERS IN JAPAN128

    TABLE 22: NGS-BASED GENE PANEL TESTS FOR CANCER DIAGNOSTICS IN JAPAN

    TABLE 23: CORE HOSPITALS DESIGNATED FOR CANCER GENOMIC MEDICINE ACROSS JAPAN

    TABLE 24: DISEASES AND ANEUPLOIDIES COMMONLY TESTED BY NIPT ASSAYS

    TABLE 25: SELECTED LIST OF NGS-BASED NIPT TESTS IN THE GLOBAL MARKET

    TABLE 26: NEW-BORN SCREENING PROGRAM IN JAPAN: INCIDENCES OF DISEASES TARGETED

    TABLE 27: SELECTED INSTITUTIONS IN JAPAN ACTIVE IN NGS RESEARCH/ RESEARCH SERVICES

    TABLE 28: SELECTED LIST OF LARGE SCALE GENOME-WIDE SEQUENCING (GWS) PROJECTS IN JAPAN

    TABLE 30: SELECTED LIST OF NGS PRODUCTS OFFERED BY 10X GENOMICS

    TABLE 31: SELECTED LIST OF PARTNERSHIPS AND ACQUISITIONS OF 10X GENOMICS

    TABLE 32: SEQUENCERS PRODUCED AND MARKETED BY THE BGI GROUP

    TABLE 33: NGS-BASED ASSAYS AND SERVICES PROVIDED BY BGI GROUP

    TABLE 34: SELECTED LIST OF RECENT PARTNERSHIPS OF BGI GROUP*

    TABLE 35: ACQUISITIONS AND PARTNERSHIPS RELATED TO ROCHE’S NGS BUSINESS

    TABLE 36: SELECTED LIST OF PARTNERSHIPS AND COLLABORATIONS OF FOUNDATION MEDICINE

    TABLE 37: GENETIC TESTING OFFERED UNDER GENELIFE BRAND BY GENESIS HEALTHCARE

    TABLE 38: SELECTED LIST OF SEQUENCING SYSTEMS OFFERED BY ILLUMINA

    TABLE 39: SELECTED LIST OF ASSAYS OFFERED BY ILLUMINA

    TABLE 40: SELECTED LIST OF PARTNERSHIPS TARGETING DIAGNOSTICS APPLICATIONS

    TABLE 41: GENE PANEL TESTS OFFERED BY MACROGEN

    TABLE 42: SELECTED LIST OF PARTNERSHIPS AND COLLABORATIONS OF MACROGEN*

    TABLE 43: SEQUENCERS PRODUCED BY OXFORD NANOPORE TECHNOLOGIES

    TABLE 44: SELECTED LIST OF RECENT PARTNERSHIPS OF OXFORD NANOPORE TECHNOLOGIES

    TABLE 45: SELECTED LIST OF THE PRODUCTS OFFERED BY PACBIO

    TABLE 46: SELECTED LIST OF PARTNERSHIPS OF PACBIO IN THE LAST 5 YEARS

    TABLE 47: SELECTED NGS PRODUCTS OF PERKIN ELMER

    TABLE 48: SELECTED LIST OF PARTNERSHIPS OF RIKEN GENESIS

    TABLE 49: PARTNERSHIPS AND COLLABORATIONS OF TAKARA BIO IN THE PAST 5 YEARS

    TABLE 50: SELECTED PARTNERSHIPS AND ACQUISITIONS OF THERMO FISHER (2017-2020)

    TABLE 51: NGS INSTRUMENTS OFFERED BY THERMO FISHER SCIENTIFIC

    TABLE 52: SELECTED LIST OF NGS-BASED ASSAYS AND SERVICES OF THERMO FISHER SCIENTIFIC

  • 10x Genomics Inc
    Agilent Technologies
    BGI Group
    Eurofins Scientific
    F. Hoffman-La Roche Ltd
    Foundation Medicine, Inc.
    Genesis Healthcare Co., Japan
    GeneQuest Co., Ltd
    Genewiz (Japan Genewith Co., Ltd)
    Illumina
    Macrogen, Inc
    Oxford Nanopore Technologies
    Pacific Biosciences
    Perkin Elmer, Inc
    Qiagen N. V.
    Riken Genesis Co., Ltd
    Sysmex Corporation
    Takara Bio Inc
    Thermo Fisher Scientific